With the development of foreign economy and trade in our country, the demand for business English talents with innovative thinking and ability is becoming more and more urgent. Combining the concept of innovation and entrepreneurship training into the business English teaching and professional construction, exploring and constructing a scientific and reasonable curriculum system that meets the needs of the current professional business English professional development and fosters innovation and entrepreneurship, is of great significance to improve the level of innovation and entrepreneurial talents training for Business English majors and satisfy the society's demand for talents. This paper analyzes the problems existing in the innovation and entrepreneurship education of Business English majors in colleges, and then explores effective ways of business English teaching reform. The current situation of business English translation will be mainly discussed. In light of the problems and insufficiencies in professional business English translation teaching, a strategy for constructing innovative business English translation is proposed, which will provide some reference for the schools to cultivate skilled talents who meet the social needs.