ESP is characterized by its uniqueness in terms of purposes, social environment, speech functions, and linguistic register, and the ESP courses are carried on according to learners’ particular objectives and requirements. Hutchinson and Waters (1987) emphasized that ESP is a teaching approach, a teaching guideline or a concept. The ultimate goal of ESP is to cultivate learners’ English communication ability in working environment. Under the context of globalization, more talents will be engaged in international exchanges, which press for the English intercultural communication ability, which is also one of the essential qualities for international-oriented talents. ESP learning could not remain at the level of conversation or the English expression of professional terms. The consciousness of intercultural communication shall be built. In order to let students feel deeply, teachers could apply situational analysis, the comparison method, and so on in ESP class. Teachers could display the would-be communication occasions, help them analyze intercultural problem under different occasions. Students could even be asked to impersonate a particular scene. The communicative situations students might meet would be a factor determining the learning contents. In addition, the cultural differences between China and western countries lie in social system, values, and way of thinking, etc. When it comes to the specific cultural content, comparison methods could be applied to deeply understand the cultural differences. The ESP class could be designed for effectively improving intercultural communication ability.