Constraining the dissolved neodymium (Nd) cycle in the ocean is paramount for using Nd isotopic composition (εNd) as a tracer to reconstruct deep-sea paleocirculations or continental weath-ering on different time scales. Dissolved εNd has been measured in seawater samples from six hydro-logical stations collected along 89°E North-South transect in the Bay of Bengal (BoB) in order to assess the impact of seasonal freshwater and sediment discharges from the continental river system. Seawater samples collected in this study during June 2012 reveal more radiogenic εNd (a difference of 2 Epsilon units for the upper 2000 m, and 0.5 Epsilon unit below 2000 m) and 3-8 pmol/kg lower Nd concentrations than the reported values of nearby seawater samples collected in November 2008. These observations are most plausible explained by a seasonal variation in dissolved Nd concentrations and εNd in the BoB, induced by seasonal variations in the freshwater and sediment discharges from the G-B river system. Based on the modern seawater Nd results, ɛNd of mixed planktonic foraminifera from core MD77-176 from an intermediate depth in the Northern Indian Ocean are selected to reconstruct the past evolution of intermediate water during deglaciation. The ɛNd record in the Northern Indian Ocean displays two pulse-like shifts towards more radiogenic Southern Ocean values during the deglaciation, and these shifts coincide with excursions in Δ14C and ɛNd records in the Pacific and Atlantic Oceans. These results suggest invasion of AAIW into the Northern Hemisphere oceans associated with enhanced Southern Ocean ventilation during deglaciation. Our new ɛNd record strongly supports the close linkage of AAIW propagation and at-mospheric CO2 rise through Southern Ocean ventilation during deglaciation.