Abstract: [Background] The Qinghai-Tibet railway (QTR) has been under constant threat from aeolian sand since its opening, and the Cuona lake section is one of the worst areas along the railway line, wind-sand disaster seriously threatening the safety of railway operation. [Methods] To evaluate and optimize the current protective system scientifically, the wind-sand two-phase flow is simulated using the Eulerian model of Fluent software. It is clear the two-phase flow rules around sand fences combined with visual analysis and the theory of multiphase flow. [Results] The results indicate that: 1) Numerical simulation and wind tunnel experiment with similarity flow, and numerical simulation has higher measurement resolution can provide more accurate results. 2) Flow transition when contact with the upper part of the sand-blocking fences, when passing through the sand-blocking fences a large amount of energy was lost. In the present protective system, the average energy loss between railway subgrade and the sand-blocking fences is 64.31%, and the effective protection distance is over 74.37%.3) The sand particles are locally enriched by the vortex, and start to deposit from within 1~3H of the sand retaining wall. With the continuous deposition of sand particles, the initial deposition position is moving forward, and the protective effect is continuously weakened. The low-speed flow area expands continuously with the second sand block fence buried by sand. 4) According to the flow structure characteristics flow field, functional areas are divided into five parts. Sand particles will settle in the dissipation deceleration area and vortex settlement area, to achieve the protective effect. [Conclusion] In the absence of sand material deposition, the current protective system can play a better protective effect. However, with the deposition of sand material, the protective effect is gradually weakened. When construction protection system in the future, the structure of fences can be reasonably improved and reasonable spacing of fences can be set according to the dynamic characteristics of wind-sand two-phase flow. This paper provides relevant theoretical basis and scientific support for the construction of the protective system in the strong wind area in the future.