In order to study the effects of different processes on the surface roughness, surface grain size and surface residual stress of aluminum alloy 6061, an experimental study of ultrasonic rolling processing was carried out considering the effects of four factors on the surface characteristics: rolling times, spindle speed, feed rate and static pressure. The surface roughness, surface grain size and surface residual stress were measured by using white light interferometer, DM4M optical microscope and drilling method. The experimental results show that the surface roughness of the material is reduced to 1/10 of the original one after ultrasonic rolling processing, the surface roughness decreases and then increases with the increase of rolling times, increases with the increase of spindle speed, increases slowly and then increases sharply with the increase of feed speed, and tends to level off and then increases sharply with the increase of static pressure. The surface residual stress changes from tensile stress to compressive stress, the maximum compressive stress can reach -650MPa, the maximum compressive stress layer can reach 0.8mm, the surface residual compressive stress increases with the increase of rolling times, and increases with the increase of static pressure; the surface grain size increases with the increase of rolling times, increases with the increase of static pressure, decreases with the increase of feed speed, and increases with the increase of spindle speed. The maximum grain size is 1.4 mm. The maximum grain size is 1.466. This paper can provide some reference significance for the research and preparation process of aluminum alloy 6061 surface nanosizing.