Today, industrial ecology, green chemistry, sustainability and eco-efficiency are directing the next generation of biomaterials, electronics, energy and environment. The increasingly scarce fossil-driven resources in the world drives the use of alternatively renewable and sustainable materials. Among these, natural wood is currently a hot matter of intensive investigations due to its huge earth storage, renewability, biodegradability with multiscale structures. Wood is composed with unique structures (etc. porosity, anisotropy, fiber) and components (etc. cellulose, semicellulose and lignin). The disintegration and reconstruction in nanostructured wood is rapidly reshaping the development of composites, electronics, energy and envirnment fields, pushing them from conventionally environment-hardous to eco-friendly and sustainable systems. In his past work, we make great efforts to understand and discover the characteristics of processing sustainable wood into advanced wood materials from nanoscale to microscale by controllable surface dissolution technology. Varying the size of porosity starting from cell lumen is attractive to the design of biocomposites of noise reduction and artificial formaldehyde-free boards, which has been carried out on a large-scale production. By controlling destroying the porous wood structures, processing wood into cellulose nanofiber and nanopaper with outstanding mechan-optical property, rendering fascinating applications in flexibly optical electronics and devices. In-situ growth of nanomaterial structures (etc., ion, catalysis) in cell cavities of wood is of special interest due to its highly ordered honeycomb structures. All the results bring a new concept that by controlling the cell cavities and wall of wood from micro to nanoscale.