56 / 2021-10-14 21:53:20

A preliminary study of real-time imaging for MR guided vascular intervention and image quality assessment

Interventional MRI,real-time imaging sequences,3D printed,image quality

Background: Interventional MRI have significant benefits for image-guided intravascular intervention and related vascular procedures. Real-time MRI could provide a radiation-free alternative to X-ray guidance of cardiovascular catheterization, enables superb tissue contrast depiction in multi-contrast imaging without administration of contrast agent. In this study, we evaluated the image quality of two MR real-time sequences, fast low angle shot (FLASH) and true fast imaging with steady-state precession (True FISP), for MR guided vascular intervention using MR compatible guidewire and balloon in a 3D printed aorta phantom.



Methods: In this study, an MR guided intervention system were setup, which consisted of a 3T scanner (MAGNETOM Skyra, Siemens Healthcare, Erlangen, Germany) and MRI compatible monitor (Fuqing Medical Technology Co., Ltd, Hefei, Anhui, China).  All experiments were performed using a peripheral balloon catheter (PTA35-6040B, DK MEDTECH, Suzhou, Jiangsu, China), which filled with 0.8ml 1% Gadodiamide mixed with normal saline and magnetic resonance compatible guidewire (diameter=0.035 in, length=150cm) (EPflex, Dettingen an der Erms, Germany). Guidewire consisted of a high-strength para-aramid synthetic fiber core, surrounded by a bending-resistant high-performance polymer and a hydrophilic coating, the markers in the guidewire were discretely mosaicked for navigation. All experiments were performed in a 3D printed aorta phantom printed by 3D printer (SPS250j, Shaanxi Hengtong Intelligent Machine Co., Ltd, Shaanxi, China.). The aorta phantom was made of transparent resin with CTA data from a normal adult (Fig 1). The interventional procedure was guided and recorded by FLASH and True FISP. The parameters of the real-time imaging sequence were: (1) FLASH, TR/TE =6.8/2.65ms, FA=12º, FOV=360×147mm, Slice thickness=10mm, Phase partial Fourier=6/8, bandwidth=230Hz/Px, (2) True FISP, TR/TE =321.35/1.88ms, FA=49º FOV=360×144mm, Slice thickness=10mm, bandwidth=1116Hz/Px.

The real-time images were evaluated objectively and subjectively. For objective assessment, the image signal-to-noise ratio (SNR), contrast noise ratio (CNR), geometric distortion, and image uniformity of two sequences were measured. The signal intensity and noise at different positions of the image were measured and their mean value was taken to calculate the SNR. The SNR was calculated by:

SNR=Signal_{normal saline}/SD_noise. 

The CNR between gadolinium-filled balloon and normal saline in the phantom was measured. The CNR was calculated by:CNR=|Signal_balloon-Signal_{normal saline}|/SD_noise.

Regarding image uniformity, most areas of multiple images were measured, and the mean value of their uniformity was calculated. The image uniformity was calculated by:U={1-(Signal_max-Signal_min/Signal_max+Signal_min)}*100%.

In terms of geometric distortion, the actual length of the gadolinium balloon and its length in the image was measured, and then the geometric distortion was calculated by:GD=|Length_image-Length_actual|/Length_image*100%.

For subjective assessment, Likert scoring was applied to assess the image sharpness, image distortion, and artifacts of all sequences. The images quality was scored subjectively by two experienced radiologists with more than six-year practice. The evaluation criteria were as follows: 1 points = poor image sharpness with serious distortion or artifacts, 2 points = medium image sharpness with medium distortion or artifact, 3 points = good image sharpness with slight distortion or artifacts, 4 points = excellent image sharpness with no distortion or artifacts.

The results of the objectively and subjectively analyses were compared between the two sequences using independent sample T-test by IBM SPSS Statistics 26.

Results: Both sequences temporal resolution was 2 frames/s and spatial resolution was 1.1×1.1×10mm (Fig 2). For objective assessment the two sequences (FLASH vs True FISP) showed significant different SNR (102±16 vs 618±137, p<0.05) and CNR (73.5±18 vs 162.2±46, p<0.05). Image uniformity (80%±6% vs 74%±4%, p=0.133) and geometric distortion (2%±1%, 2%±1%, p=0.717) did not showed significant difference. Two radiologists reached agreement on subjective scoring. The subjective scores of two sequences did showed significant difference, and the FLASH score was higher than the True FISP score (FALSH=3.7±0.5, True FISP=3.1±0.9, p<0.05).

The artifacts of the guidewire were moderate for FLASH, and the balloon was high signal. In True FISP, the artifacts of the guidewire were severe, the balloon was low signal and blurred by the artifacts of the guidewire.

Discussion: Both sequences have sufficient SNR, CNR, image uniformity and the degree of geometric distortion was also within the acceptable range. The FLASH sequence has sufficient guiding ability in the actual application process, the artifacts of the guidewire were moderate. Although the SNR and CNR were higher for True FISP, the artifacts of the guidewire were severe, and blurred display of balloon.

Conclusions: In conclusion, the study demonstrates the MR real-time imaging, FLAH sequence, is feasible of guiding cardiovascular interventions.