Cumulative landslides are extensively distributed globally and severely threaten the survival environment and the safety of human beings. The embedded bi-geomaterial interfaces are the potential sliding surface thus playing a pivotal role in the initiation and reactivation of landslides. Although extensive researches have been conducted on the mechanical properties of interfaces, very limited studies have been reported to correlate the macroscopic morphological characteristics of interfaces to landslide deformation patterns. Aiming to identify the significance of the inherent features of bi-geomaterial interfaces on the deformation patterns of landslides developed in Huanggang area of eastern Hubei province, China, this study presents a comprehensive assessment of interface in the area, including the geological genesis, essential structure, mechanical reaction and macroscopic morphology by means of field investigation and laboratory experiments. And, we developed a generalized slope model with a bilayer interface, and analyzed a series of simulative tests by adjusting variable curvature and inclination of interface. The experimental results indicated that the shear strength difference between soil-bedrock interface (SRI) and soil-soil interface (SSI) was remarkably slight under fully saturated conditions, suggesting the possibility of destabilization along the upper SSI other than the lower SRI. Moreover, the numerical analytical results indicated that the greater the curvature of the interface, the greater the inclination of the upper SSI than that of the SRI, the more likely a destabilization develops along the upper interface. The study contributes to the understanding of failure mechanism of cumulative landslide and provides a reference for geohazards prevention and mitigation.