Edible mushroom residue has been recognized as a cheap and sustainable raw material for biological fertilizers. It is a trend of sustainable economic development of bioorganic fertilizers by composting the mushroom residue to achieve resource utilization. However, the composting technology is hindered by the shortcomings of difficult degradation of cellulose, imbalanced carbon nitrogen ratio, and unstable composting quality. At present, microbial agents have received widespread attention in composting to overcome these problems with advantages of high cellulose degradation efficiency, low cost, and easy preparation. In order to explore the ability of microbial composite agents to degrade cellulose during the composting process, we screened and isolated the high-efficiency cellulose degrading bacteria from edible mushroom residue. And the composites microbial agents were prepared to improve the composting performance in mushroom residue composting. Compared with the control group, the experimental results after 30 days of composting showed that the composting treatment inoculated with microbial compound bacteria agent entered the decomposition stage as soon as 13 days, the content of organic matter decreased by 7.1%, the content of available phosphorus increased by 1.6%, and the GI increased by 81%.The results showed that the composite microbial agents can prolong the thermophilic period of compost, promote compost maturity, and significantly improve the nutrient content and maturity of compost.It is expected to be widely used in composting of agricultural waste organic matter by adding compound microbial agent in composting process.