Rapid advances in satellite systems, sensors and communication technologies are stimulating the development of integrated multisensory systems for an increasing number of space applications. Artificial Intelligence (AI), cognitive automation and advanced networking technologies are being extensively applied to aerospace and satellite systems allowing the development of high-performance and safe multisensory mission systems. This has led to the introduction of various intelligent satellite systems concepts, opening uncharted opportunities for the new space. For future space transport operations to be technically and commercially viable, it is critical that an acceptable level of safety is provided, requiring the development of novel mission planning and decision support tools that utilize advanced Communication, Navigation and Surveillance (CNS) technologies, and allowing a seamless integration of space operations in the current Space Domain Assurance (SDA) /Space Traffic Management (STM) network. Recent research is turning greater attention to on-orbit phase, where the unique hazards of the space environment are being examined and the necessary elements required for space object de-confliction and collision avoidance modelling are analysed. This presentation will address recent advances in autonomous trajectory optimisation for intelligent satellite systems with a view to trusted autonomy and resiliency. The evolution of regulatory frameworks supporting spacecraft operations with a view to successfully developing sustainable business models, including space debris mitigation strategies, operational risk assessment and liability issues will be addressed. Lastly, adequate modelling approaches to meet on-orbit risk criteria must be developed and evolutionary requirements to improve current operational procedures (regulatory frameworks) are highlighted to support transition to a fully integrated Multi-Domain Traffic Management (MDTM) in a bid to support future mining operations.