Open-pit mining has the advantages of a short construction period, large mining scale, low production cost, and high resource recovery rate. At present, the depth of open-pit mining is increasing, the slope height and disturbance area are further increased, and the problem of slope instability is becoming more and more serious. Therefore, it is important to monitor the slope and evaluate its stability for the production safety of open-pit mines. Conventional ground monitoring technologies are difficult to fully obtain the temporal and spatial variation information of the whole mining area. Fortunately, remote sensing can overcome these limitations because of its wide-coverage advantages, short revisit period, high economic benefits, and rich access to information. In this paper, taking Xinjing Open-pit Mine, Inner Mongolia as the study area, the remote sensing interpretation, D-InSAR, and DS-InSAR methods were employed to monitor the collapse area and dump slope on 22 February 2023 based on GF-2, Radarsat-2, and Sentinel-1A data. The results show that: The subsidence of the discharge fields' slopes happened during the observation period, and the combination of topography and time-series subsidence results inferred a low risk of landslides in these areas. The monitor results obtained from Radarsat-2 show that the subsidence in the landslide collapse area is large, with a maximum subsidence value of -70 mm in 23 days. The multi-source remote sensing technology can comprehensively and accurately monitor the spatial-temporal changes, and then effectively identify and locate potential risk high-risk areas, which is of great significance for pre-disaster warning and post-disaster relief.