Gesture recognition is an indispensable component of natural and efficient human-computer interaction technology, particularly in desktop-level applications, where it can significantly enhance people’s productivity. However, the current gesture recognition community lacks a suitable desktop-level (top-view perspective) dataset for lightweight gesture capture devices. In this study, we have established a dataset named GR4DHCI. What distinguishes this dataset is its inherent naturalness, intuitive characteristics, and diversity. Its primary purpose is to serve as a valuable resource for the development of desktop-level portable applications. GR4DHCI comprises over 7,000 gesture samples and a total of 382,447 frames for both Stereo IR and skeletal modalities. We also address the variances in hand positioning during desktop interactions by incorporating 27 different hand positions into the dataset. Building upon the GR4DHCI dataset, we conducted a series of experimental studies, the results of which demonstrate that the fine-grained classification blocks proposed in this paper can enhance the model’s recognition accuracy. Our dataset and experimental findings presented in this paper are anticipated to propel advancements in desktop-level gesture recognition research.