Real industrial operating systems are not ideally immune to unmodeled dynamics, and industrial processes usually operate on multiple time scales, which poses a problem for operational optimization of industrial processes. In order to better address these difficulties, a composite compensated controller is designed to solve the input-constrained optimal operation control (OOC) problem in dual time scales by integrating reinforcement learning (RL) techniques and singular perturbation (SP) theory. Within this control framework, a self-learning compensatory control method is proposed to optimize the operational metrics of a dual time-scale industrial system with uncertain dynamic parts to the desired values. Finally, the effectiveness of the method is verified by an industrial mixed separation thickening process (MSTP) example.