In order to meet the urgent needs of satellite measurement and control communication in the whole process under the complex environment, multiple ground measurement and control stations and satellite measurement and control sub-systems must work closely together, and at the same time, with the continuous development of multi-channel spread spectrum technology and multi-station ranging system. In order to solve the problem of multi-access interference in the simultaneous establishment of multi-station measurement and control and ranging channels, we analyze the working principle of the simultaneous reception of measurement and control and ranging signals by the on-board transponder, and analyze the autocorrelation function, the mutual correlation function characteristics and the mutual influence of the PN sequences in the same code group by using MATLAB simulation to derive a quantitative relationship between the signal energy of the measurement, control and ranging multi-access signals, as well as the characteristics of the multi-access interference.