21 / 2024-10-10 19:46:11

Recombinant Proteins of Newcastle Disease Virus as a Vector for Vaccine Development

Newcastle disease virus (NDV) is a highly contagious avian virus that affects poultry worldwide, leading to significant economic losses. NDV strains vary in virulence, with low-virulent strains such as LaSota and B1 widely used as vaccines. Advances in reverse genetics have enabled the manipulation of NDV as a vaccine vector for both human and animal diseases due to its strong immune response, safety, and ease of genetic modification.
This study aims to produce recombinant NDV proteins to develop a universal vector for vaccine design. Key immune-related genes were selected, and chimeric plasmids were created for bacterial expression. The research is supported by the Ministry of Science and Higher Education of Kazakhstan (IRN No. AP23489437/GF-MNVO-RK) from 2022–2024.