37 / 2024-10-14 16:48:08

An E. coli phage isolated from a wild animal

E. coli can cause local or systemic infections in a variety of wild animals, including sepsis, enteritis and abscesses. The overuse of antibiotics has led to the emergence of antibiotic resistance in E. coli in the wild, seriously affecting the health of wildlife and wildlife rescue. Phage is a kind of virus that can attack bacteria and has strict host specificity. Lytic phage can efficiently lyse host bacteria without negative effects on animal body. These advantages make it a hot spot to replace antibiotics in the treatment of infectious diseases. In this study, using a sika deer strain of E. coli as the host strain, the phage was isolated, and its biological characteristics and genomic characteristics were investigated, so as to provide theoretical basis for the development of antibacterial agents for drug-resistant E. coli.