46 / 2024-10-21 21:12:11

The PB1 protein of H9N2 influenza A virus inhibits antiviral innate immunity by targeting MAVS for TRIM25-mediated autophagic degradation

Influenza A virus (IAV) can infect a wide range of hosts (avian, porcine, equine, human, etc.) and trigger large-scale epidemics or pandemics through cross-species transmission. Studying how IAV replicates and spreads in animals by evading immune surveillance could help stop the chain of transmission between humans and animals, in line with One health. IAV encodes proteins that evade the innate immune system through various strategies to facilitate its replication. However, the mechanism by which H9N2 PB1 regulates IFN-I remains unknown.