47 / 2024-10-21 22:01:10

Exosome/antibiotic biohybrid for therapy of liver abscesses（外泌体/抗生素杂化颗粒的制备及其在小鼠肝脓肿的应用）

Bacterial liver abscess is a common disease of the digestive system caused by retrograde infection of the biliary tract, and the main causative organisms include Staphylococcus aureus and Escherichia coli. Clinical treatment of liver abscess is based on antibiotics, but due to the lack of targeting of antibiotics to the infected lesion, they are often overused with poor efficacy. In addition, overuse of antibiotics can lead to bacterial resistance and residual toxicity. There is an urgent need to develop novel antibiotic-targeted drug delivery strategies to reduce the use of antibiotics and improve the therapeutic efficacy of liver abscesses. This project utilizes the metastatic properties of colon cancer to load antibiotics into the exosomes of colon cancer cells for the targeted treatment of liver abscesses.
细菌性肝脓肿是由于胆道感染逆行而引起的一种消化系统的常见疾病，主要致病菌包括金黄色葡萄球菌、大肠杆菌等，其发病率逐年升高。临床上肝脓肿的治疗主要是采用抗生素，包括第三代头孢菌素、氨基苷类、喹诺酮类等药物。但由于抗生素缺乏感染病灶靶向性，常过量使用且治疗效果较差。此外，过量使用抗生素会导致细菌耐药性的发生与毒性的残留。亟需开发新型抗生素靶向递送策略，用于降低抗生素的使用，提高肝脓肿的治疗效果。本项目利用结肠癌易转移的特点，将抗生素负载于结肠癌细胞的外泌体中，用于肝脓肿的靶向治疗。本项目的实施，将为肝脓肿治疗制剂的开发提供新的思路，对于缓解细菌耐药性具有重要意义。同时我们也会构建动物模型，在小鼠中检测其治疗效果，以减少动物疾病发生，应用到人体治疗，从而达到“全健康”。