The CCCH-type zinc finger antiviral protein (C3H-ZAP) is capable of recognizing and promoting the degradation of mRNAs and proteins associated with specific viruses, in addition to exerting its antiviral effects through the activation of T cells. Furthermore, traditional Chinese medicine polysaccharides (TCMPs) exhibit broad-spectrum antibacterial and antiviral properties and can significantly enhance the immune response in avian organisms. Our objective is to develop an innovative pharmaceutical compound by integrating C3H-ZAP and TCMPs, and to administer it in a manner that minimizes physiological stress in poultry. This approach is designed to effectively prevent and treat avian immunosuppressive diseases.