57 / 2024-10-23 20:52:09

Alkaline mineral complex as an antibiotic substitute to inhibit the spread of pathogenic microorganisms in pig intestine

At present, microbial drug resistance has become a major challenge in the field of global public health, and human health is closely related to animal health. Disease control is an important index reflecting the production level and economic benefit of pig breeding. Basic mineral complexes (AMC) have been widely studied and reported in promoting intestinal health, anti-inflammatory and antioxidant activities. In our previous studies, AMC contains non-specific immune stimulants that can promote piglet growth and intestinal barrier. However, whether AMC can confer diarrheal resistance in diseased piglets and inhibit the spread of pathogenic microorganisms in pig intestines is an urgent question to be solved in the era of "Reduce antinostasis". In this study, the PRV/ PEDV-infected piglet model and the in vitro model of Vero, IPEC-J2 and ST cells were constructed, and multi-omics was combined to explore the ability and mechanism of AMC inhibiting pathogenic microorganisms. It was found that AMC inhibited the transmission of pathogenic microorganisms and inhibited viral synthesis by regulating the metabolism of glycerol and glycerophospholipid. The GPAT2/FXR axis further regulates lipid metabolism and inhibits viral replication, which is expected to be a new antidrug. The aim of this study was to analyze the antimicrobial action of AMC and provide a new idea for the study of "substitution".