This poster explores the urgent need for a “One Health” approach to address the global challenge of antibiotic resistance. It highlights the interconnectedness of human, animal, and environmental health, emphasizing how overuse of antibiotics negatively impacts all three. The poster depicts how antibiotics disrupt the delicate balance of gut microbiota, leading to problems like increased susceptibility to infections, digestive issues, and even chronic diseases. The poster then introduces a promising alternative: functional polysaccharides. It outlines how these natural compounds, found in sources like Jerusalem artichoke and jujube, act as prebiotics, promoting the growth of beneficial gut bacteria and regulating the production of beneficial metabolites. By reshaping a healthy gut microbiome, functional polysaccharides can help to improve digestion, enhance the immune system, and reduce the need for antibiotics. This poster emphasizes the potential of these natural compounds to reshape the gut microbiome, leading to a healthier future for both humans and animals. The poster advocates for a shift towards a holistic approach to health, where solutions address the interconnectedness of all living systems, creating a more sustainable and resilient future for all.