63 / 2024-10-24 11:59:35

Fecal microbial transplantation alleviates pyroptosis-mediated intestinal damage in piglets by modulating tryptophan metabolism

Intestinal inflammation is widespread in piglets; we used FMT intervention and explored the mechanisms in depth. Our data suggest that FMT can alleviate intestinal damage in piglets by promoting colonization of Lactobacillus reuteri to activate tryptophan metabolism to up-regulate IAA, IAId, and ILA levels and by activating AhR to attenuate the expression of proteins associated with pyroptosis.