71 / 2024-10-25 08:04:09

Nanobody-based diagnostic techniques, vaccines and drugs for the prevention and treatment of animal diseases

Animal diseases pose a significant threat to human health, with over 60% of infectious cases in humans originating from pathogenic agents associated with animals. Moreover, animal diseases are a critical factor impeding the sustainable development of global animal husbandry. Therefore, it is essential to advance diagnostic techniques, therapeutics and vaccines for the prevention and control of these diseases. Nanobodies (Nbs) are derived from the variable domains of heavy chain-only antibodies (VHH) found in camelids and sharks, exhibiting a range of exceptional biological properties. They are characterized by ease of expression and modification, high stability, strong antigen-binding affinity, excellent solubility, robust permeability, and low immunogenicity. These attributes underscore their potential as alternatives for applications in structural biology, elucidating biochemical mechanisms, as well as in the diagnosis and treatment of diseases.In this research, we have established a Nbs screening and preparation platform, as well as a Nbs fusion and multimerization affinity modification technology platform for screening and modify specific Nbs against the pathogens of animal diseases.