Since modern times, antibiotics have been widely used as feed additives in animal husbandry industry, which has significantly reduced the cost of breeding. However, the widespread use of antibiotics in agriculture has led to the spread of drug-resistant bacteria, which not only seriously threatens human health, but also poses great risks to animal health and environmental safety. In view of this, the “prohibition of resistance” of feed has become a global consensus. However, this move has increased the mortality rate of livestock and pushed up the cost of breeding. In order to promote the sustainable and high-quality development of agriculture, it is urgent to find substitutes for antibiotics.