83 / 2024-10-25 20:02:39

Advancing One Health: Unraveling PCV2's Impact on T-Cell Differentiation for Host Immunity Enhancement and Viral Resistance

Porcine circovirus type 2 (PCV2) is one of the major challenges faced by the global pig industry. Infections caused by PCV2 lead to decreased immunity, slow growth, and increased mortality rates in pigs, which in turn affect food security and economic development all over the world. PCV2 not only poses a threat to pig health but also has the potential to affect human health through the food chain, becoming a potential risk for zoonotic diseases. This study delves into the impact of PCV2 on T-cell differentiation and the function of regulatory T cells (Treg cells), which is crucial for developing effective control strategies, ensuring pig health, and promoting sustainable economic development. For the first time, this study systematically explores the effects of PCV2 on T cells and Treg cells, as well as the key mechanisms involved, providing new insights into the pathogenesis of PCV2 and the development of therapeutic drugs. The research outcomes aim to implement the "ONE WORLD, ONE HEALTH" concept, emphasizing the close connection between human, animal, and environmental health, and hold significant scientific value and social importance.