96 / 2024-10-26 09:39:10

Microcins as Aids for Human and Animal Health

Microcins, antimicrobial peptides isolated from Enterobacteria, facilitate the transformation of sustainable agrifood systems by reducing antimicrobial dependence. They offer a new solution for the development of antibiotic-substitute technologies for animal bacterial diseases, with Microcin Y effectively resisting Salmonella Pullorum infection and EcN-C2 resisting pathogenic E. coli O78 infection in chickens. Additionally, Microcins promote human intestinal fitness by regulating intestinal flora and affecting the brain-gut axis, with Microcin Y specifically balancing intestinal flora through digestive tract interactions and metabolism. Furthermore, Microcins exhibit antimicrobial activity against multidrug-resistant and zoonotic bacteria in the environment, making them a potential replacement for antibiotics in treating these resistant bacteria.