98 / 2024-10-26 10:59:51

One Health:Acute PE-MPs exposure activates the intestinal mucosal immune network pathway in adult zebrafish.

Microplastics, defined as plastic particles smaller than 5 millimeters in diameter, originate from the breakdown of various plastic products such as plastic bags, takeout containers, and bottles. These microplastics can enter water bodies, soil, and air, and subsequently infiltrate the food chain，which also can enter the human body through ingestion, inhalation, and skin absorption, posing negative impacts on our health.The intestinal goblet cell coverage was increased in T1 but decreased in T100 and T1000; the gill filament and skin mucous cells had no obvious histological changes. Elevation of the intestinal complement C3 and C4 in T100 seems to be cause by the intestinal inflammation. PE-MPs increase the infection probability in the intestinal mucosa by altering the abundance of intestinal dominant microbiota at the level of phylum. PE-MPs exposure activated the intestinal immune network pathway for mucosal immunoglobulin production in T100 and T1000 for 7 days.