Considering the importance of sturgeon and the fact that these fish with high economic value are in danger of extinction , it has led to a shortage of healthy and quality sturgeon fry. One of main bottlenecks in the production of sturgeon fry is their high mortality. Mortality is due to various stress factors such as increasingly density movement and sudden changes in temperature, water and oxygen, water quality and feed appropriate to the needs of aquatic animals at different weights or even pathogens. Stress management in aquaculture through the use of additives or medicinal feeds (functional foods) is considered an ideal strategy. The aim of this review research is to emphasize the combined use of dietary anti-stress agents to prevent various stresses in sturgeon fry. Depending on the species, using effective combined anti-stressors with relevant stresses in different culture systems can be used to determine the optimization and efficiency of production management of sensitive sturgeon fry. This review article examines the effects of compounds such as astaxanthin, vitamin E, and selenium on improving the physiological performance of Beluga (Huso huso) under environmental stress conditions. The combination of these antistressors can produce synergistic effects in dealing with environmental stresses and improve productivity in aquaculture. This article also provides suggestions for future research in the field of combined use of antistressors in aquaculture under different stressful conditions.