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Chemical total synthesis of a compound found in fugus Rhizopus sp. W23: Norcyclocitrinoic acid A

Deep Sea fungus,Rhizopus sp. W23,Norcyclocitrinoic acid A,Total synthesis,Proposal of synthesis,Bicyclic [4.4.1] ring system,Retrosynthesis,tetracyclic steroid

The diversity of marine microorganisms and fungi has led to various chemical extracts, some of which have specific medicinal values. Norcyclocitrinoic acid A extracted from the deep-sea fungus Rhizopus sp. W23 has a unique tetracyclic steroid structure, which makes it possible to have anti-osteoporotic activity. This article opens up a whole new way of thinking about the pure chemical synthesis of Norcyclocitrinoic acid A. A very detailed synthetic pathway is explained in this article. In addition, a sugar-like structure and a Vitamin C-like structure were found in the synthesis, providing a basic idea for the future synthesis of more fungal extracts. Furthermore, the article suggests many directions for further research and experimentation.