3 / 2025-06-20 16:18:56

The retrosynthesis and proposed forward synthesis of Peniditerpenoids A, extracted from Mangrove-Sediment-Derived Penicillium sp. for the treatment of Osteoporosis

Peniditerpenoid,retrosynthesis,synthesis,carbonyl,organic

Recently, two natural products, named Peniditerpenoids A and B were extracted from Penicillium sp. SCSIO 41411 in the mangrove-sediment-derived fungus. The former, a di-seco-indole diterpenoid, Peniditerpenoid A has a great effort in treating osteoporosis. Its pharmaceutical mechanism can be simply indicated in the following figure. In literature-studies verified that Peniditerpenoid A successfully inhibited the activation of TAK1 and then prevented the phosphorylation of I_kBα  and the translocation of the p65 cell – the subunit of NF-kB. Besides, the levels of NF-kB activation and NFATc1 transcription were both reduced to some extent. Finally, the differentiation of RANKL-induced osteoclasts in bones was eliminated obviously, and the symptoms of osteoporosis gradually got better. Therefore, it is necessary to explore the chemical synthesis of this natural molecule. In the following paper, the basic concepts of retrosynthesis strategy were first introduced and then focused on the whole synthetic pathways of Peniditerpenoid A by using the sense of forward retrosynthesis result in organic chemistry fields. To be aware, the result relied on the theoretical result rather than experimental support.