The Uragen lead-zinc ore deposit,located in Kashi Sag on the northwestern margin of the Tarim basin of Xinjiang,is a sandstone-type ore deposit in petroliferous basin. According to analysis of regional-scale strata, sedimentary rocks and recent prospecting data,this paper studies the characteristics of clastic rock controlling of the Uragen ore deposit. It is suggested that the Paleocene Uragen formations are significant ore-bearing strata,which is a set of regressive sand,gravel,mud-carbonate sedimentary formation. The mineralization zone develops in the contact between the second bed of first lithologic member of Uragen group and the dolomitic limestone (breccia). Those regularly tabular ore bodies are consistent with the occurrence of stratum. The mineralization is related to the type of clastic rocks, which descends from conglomerate glutenite, pebbly-sandstone, sandstone, to mudstone. The peak of this mineralization happens in the dolomitic limestone, some of which is brecciated. It is formed by deuteric hydrothermal process. The ore body is mainly massive or small veined. The bigger grain size is, the greater mineralization is. We conclude that the Uragen ore deposit was obviously controlled by the syncline of Uragen and the late extensional fracture structure. The major bodies mainly distributed in gravel strata and dolomitic limestone (breccia). Pyrite type lead-zinc ore were found in some part of the extensional fractures, which were developed in the adjacent areas between the orebody and its upper dolomitic limestone (breccia).