We are experiencing an era of profound transformation when mobile ubiquitous connection makes possible a real innovation of healthcare and wellbeing services. The market availability of devices that are deeply integrated in everyday objects like watches and garments also enhance the possibility to have a continuous monitoring of parameters and functions. We operate in this infinitely mutable and extraordinarily fast scenario, with the aim to design innovations and new perspectives without forgetting the human dimension which is the key and driving factor. For many years, technology has been the hub of innovation and development, forgetting that systems and devices are developed for humans, who should be the center of the entire process indeed. Starting from the human dimension, taking a cue from disciplines such as ergonomics and design, can help researchers to develop and implement real tools fitting into everyday objects and life. To do that we need to use a specific approach during the design process; design thinking and Human-centered design (HCD) can be a good starting point for develops solutions to problems by involving the human perspective in all steps of the problem-solving process. This creative method has the aim to make systems usable and useful, focusing on the users, designing around their needs and requirements at all stages, and by applying human factors/ergonomics, usability knowledge, and techniques. This approach enhances effectiveness and efficiency, improves human well-being, user satisfaction, accessibility and sustainability; and counteracts possible adverse effects of use on human health, safety and performance. With this workshop we would discuss on the relationship between design process, human factors and technology development, trying to investigate how the implementation of human perspective can play a key role in the scenario of healthcare technologies.