Cyber-Physical Systems (CPS) are considered to be the core of Industry 4.0 that integrate the process of communication, computation and control. More specifically, by embedding modules of sensing, communication, computation into physical devices, the goals of CPS are to achieve decentralized sensing, reliable data transmission and real-time physical control with feedback loops where physical processes affect computations. Malicious attacks targeted to CPS that not only a single computer is affected, but also influence the interconnected physical world. It would lead to malfunction of devices and control systems with severe financial losses. Thus, CPS serve as critical infrastructure in our lives, their security and privacy become extremely important. This workshop aims to exploit novel solutions to CPS security and privacy challenges. Besides, the submissions about the security and privacy of the other systems such as Internet of Things, Industrial Control Systems, SCADA, Smart Grid, Transportation Systems, Medical Systems are also all welcome.