Since the introduction of the term Serious Games (SGs) in the early 2000s by Ben Sawyer to describe digital games with purpose other than pure entertainment, the field of SGs has gained substantial research interest and entrepreneurial momentum. Research and development in this field proliferated and enabled Gaming Technologies, such as VR, AR, and MxR, and SGs as valid educational and training tools, with an exponential curve of number of SGs released every year. Among other application domains, Gaming Technologies have also been widely used as tools to promote health and wellbeing and condition-specific interventions to target assessment, remote monitoring, cognitive and motor therapy and rehabilitation and for a wide span of diseases and conditions. Additionally, SGs have been used as generic exercising interventions (exer-games) aiming to improve the physical activity of the elderly, in light of active and healthy ageing. The issues created by an ageing population, highlight the need for implementation of evidence-based, innovative approaches to empower the service users (SUs) and families to support a continuum of health provision and care; and at the same time, relieve the ever-increasing pressure on respective governmental bodies to provide these services in more cost-efficient ways.