The lectures of this winter school cover a broad range of theoretical and computational methods in soft matter and biological physics. Topics include Monte Carlo and molecular dynamics simulations, multiscale and coarse-grained modeling, energetic varational theory, scaled particle theory, and applications in biology, soft materials, liquid-state physics, and complex fluids. The invited talks of the winter school will review the latest experimental and theoretical advances in the field. This winter school is financially supported by Shanghai Jiao Tong University, and research grants from National Science Foundation of China and Central Organization Department of China. No registration process is required, but participants should cover their own meals and lodges. However, if participants need a help for hotel information near campus, please contact with our secretary Ms. Qing Chen.