The 2014 Gordon Conference on Tuberculosis Drug Discovery and Development will cover the range of activities involved in discovering and producing new antibiotics to combat tuberculosis. The conference will feature discussions of target and compound discovery, new potential anti-TB compounds in development, clinical trial design and early trial results. We invite researchers interested in all aspects of drug discovery and development and welcome participants from academia, industry, government and non-governmental organizations. In particular, we invite trainees and scientists from TB-endemic countries to apply, as their contribution to the struggle against TB is especially important. All participants are asked to submit abstracts of their work for presentation as posters, and some abstracts will be chosen for oral presentations. The conference provides the opportunity to interact with colleagues in an informal and intimate atmosphere and is designed to promote extensive discussion.