Understanding how mitochondria communicate within the cell will provide important clues to elucidate its roles in normal cell physiology, as well as numerous diseases such as diabetes, neurodegeneration and cancer. The classical view of mitochondria is of an organelle that interacts with other features of cell biology primarily through the provision and consumption of metabolic intermediates and energetic products. Emerging evidence from many areas of science is accumulating to suggest that mitochondria play much more active roles in communication with other organelles, determining cell and organismal behavior. This conference will focus on these integrated behaviors and the resulting communication. The sessions will be organized around the different nodes, modes and destinations of that signaling. It will bring together people and ideas from different areas of cell biology and physiology who typically do not attend the same conferences, resulting in the development of new collaborations and concepts.